Israel's attack on Iran, its nuclear sites and its military leadership are part of Prime Minister Benjamin Netanyahu's larger ambition to reform the dynamics of the Middle East and vanquish longtime foes. With the Islamic Republic weakened by the near defeat over the past year of key proxies such as Hamas and Hezbollah, the final — and arguably most dangerous — elements of Israel's military strategy were put in play early Friday local time in Iran. "Pandora's box has been cast wide open with Israel's sweeping overnight air campaign against Iranian targets — an escalation that risks reshaping the strategic...